abstract：BACKGROUND:In a malaria-endemic area the distribution of patients is neither constant in time nor homogeneous in space. The WHO recommends the stratification of malaria risk on a fine geographical scale. In the village of Cacao in French Guiana, the study of the spatial and temporal distribution of malaria cases, durin...

journal_title：Malaria journal

authors： Basurko C,Demattei C,Han-Sze R,Grenier C,Joubert M,Nacher M,Carme B

更新日期：2013-03-11 00:00:00

abstract：:Plasmodium knowlesi is a potentially life-threatening zoonotic malaria parasite due to its relatively short erythrocytic cycle. Microscopic identification of P. knowlesi is difficult, with "compacted parasite cytoplasm" being one of the important identifying keys. This report is about a case of hyperparasitaemic human...

journal_title：Malaria journal

authors： Lee WC,Chin PW,Lau YL,Chin LC,Fong MY,Yap CJ,Supramaniam RR,Mahmud R

更新日期：2013-03-06 00:00:00

abstract：:Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades. Despite this, there is currently no licensed malaria vaccine. Research...

journal_title：Malaria journal

authors： Mwangoka G,Ogutu B,Msambichaka B,Mzee T,Salim N,Kafuruki S,Mpina M,Shekalaghe S,Tanner M,Abdulla S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...

journal_title：Malaria journal

authors： Cator LJ,Thomas S,Paaijmans KP,Ravishankaran S,Justin JA,Mathai MT,Read AF,Thomas MB,Eapen A

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become an essential tool in the contemporary malaria control and management programmes in the world. This study aims to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area. METHODS:A total 606 febrile patients in the Ch...

journal_title：Malaria journal

authors： Yan J,Li N,Wei X,Li P,Zhao Z,Wang L,Li S,Li X,Wang Y,Li S,Yang Z,Zheng B,Zhou G,Yan G,Cui L,Cao Y,Fan Q

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:The Drugs for Neglected Diseases initiative (DNDi) is a not-for profit organization committed to providing affordable medicines and access to treatments in resource-poor settings. Traditionally drug development has happened "in house" within pharmaceutical companies, with research and development costs ultim...

journal_title：Malaria journal

authors： Wells S,Diap G,Kiechel JR

更新日期：2013-02-21 00:00:00

abstract：BACKGROUND:Members of the Anopheles punctulatus group (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Understanding why only certain species are able to transmit malaria requires a better comprehension of ...

journal_title：Malaria journal

authors： Logue K,Chan ER,Phipps T,Small ST,Reimer L,Henry-Halldin C,Sattabongkot J,Siba PM,Zimmerman PA,Serre D

更新日期：2013-02-14 00:00:00

abstract：BACKGROUND:Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is cor...

journal_title：Malaria journal

authors： Dhabangi A,Mworozi E,Lubega IR,Cserti-Gazdewich CM,Maganda A,Dzik WH

更新日期：2013-02-06 00:00:00

abstract：BACKGROUND:Many studies have tracked the distribution and persistence of avian haemosporidian communities across space and time at the population level, but few studies have investigated these aspects of infection at the individual level over time. Important aspects of parasite infection at the individual level can be ...

journal_title：Malaria journal

authors： van Rooyen J,Lalubin F,Glaizot O,Christe P

更新日期：2013-01-30 00:00:00

abstract：BACKGROUND:Rosette-formation of Plasmodium falciparum parasitized erythrocytes is of importance in the development of severe malaria. The parasite-derived molecule PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1), central to rosetting, is suggested to be included in a multimeric vaccine targeting severe di...

journal_title：Malaria journal

authors： Angeletti D,Albrecht L,Wahlgren M,Moll K

更新日期：2013-01-24 00:00:00

abstract：BACKGROUND:Most of the current biophysical models designed to address the large-scale distribution of malaria assume that transmission of the disease is independent of the vector involved. Another common assumption in these type of model is that the mortality rate of mosquitoes is constant over their life span and that...

journal_title：Malaria journal

authors： Lunde TM,Korecha D,Loha E,Sorteberg A,Lindtjørn B

更新日期：2013-01-23 00:00:00

abstract：BACKGROUND:Malaria control has been dramatically scaled up the past decade, mainly thanks to increasing international donor financing since 2003. This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund, other donor and domestic malaria programme financing over 2003 to 2...

journal_title：Malaria journal

authors： Korenromp EL,Hosseini M,Newman RD,Cibulskis RE

更新日期：2013-01-14 00:00:00

abstract：BACKGROUND:The RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization. Safety, immunogenicity and efficacy of the RTS,S/AS02(D) vaccine candidate when integrated into a standard EPI schedul...

journal_title：Malaria journal

authors： Abdulla S,Salim N,Machera F,Kamata R,Juma O,Shomari M,Kubhoja S,Mohammed A,Mwangoka G,Aebi T,Mshinda H,Schellenberg D,Carter T,Villafana T,Dubois MC,Leach A,Lievens M,Vekemans J,Cohen J,Ballou WR,Tanner M

更新日期：2013-01-08 00:00:00

abstract：BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...

journal_title：Malaria journal

authors： Noone C,Parkinson M,Dowling DJ,Aldridge A,Kirwan P,Molloy SF,Asaolu SO,Holland C,O'Neill SM

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination. There has been no report yet on the potential cardiac effects of the combination artesunate-amodiaquine. METHODS:Electrocardiographic (ECG) ...

journal_title：Malaria journal

authors： Adjei GO,Oduro-Boatey C,Rodrigues OP,Hoegberg LC,Alifrangis M,Kurtzhals JA,Goka BQ

更新日期：2012-12-17 00:00:00

abstract：BACKGROUND:Malaria remains a major human health problem, with no licensed vaccine currently available. Malaria infections initiate when infectious Plasmodium sporozoites are transmitted by Anopheline mosquitoes during their blood meal. Investigations of the malaria sporozoite are, therefore, of clear medical importance...

journal_title：Malaria journal

authors： Kennedy M,Fishbaugher ME,Vaughan AM,Patrapuvich R,Boonhok R,Yimamnuaychok N,Rezakhani N,Metzger P,Ponpuak M,Sattabongkot J,Kappe SH,Hume JC,Lindner SE

更新日期：2012-12-17 00:00:00

abstract：BACKGROUND:Many recent studies have examined the impact of urbanization on Plasmodium falciparum malaria endemicity and found a general trend of reduced transmission in urban areas. However, none has examined the effect of urbanization on Plasmodium vivax malaria, which is the most widely distributed malaria species an...

journal_title：Malaria journal

authors： Qi Q,Guerra CA,Moyes CL,Elyazar IR,Gething PW,Hay SI,Tatem AJ

更新日期：2012-12-05 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:The study of the Plasmodium falciparum heavy metal transporter gene pfmdr2 employed radioactive labelled heavy metal. As the use of radioactive isotopes shrank considerably during the last few years, resulting in the cessation of the production of some isotopes, amongst them Cadmium109 which was used for tha...

journal_title：Malaria journal

authors： Rosental B,Hadad U,Sinay R,Braiman A,Porgador A,Pollack Y

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathem...

journal_title：Malaria journal

authors： Stuckey EM,Stevenson JC,Cooke MK,Owaga C,Marube E,Oando G,Hardy D,Drakeley C,Smith TA,Cox J,Chitnis N

更新日期：2012-10-29 00:00:00

abstract：BACKGROUND:The malaria parasite disposes of host-derived ferrihaem (iron(III)protoporphyrin IX, Fe(III)PPIX) by conversion to crystalline haemozoin in close association with neutral lipids. Lipids mediate synthetic haemozoin (β-haematin) formation very efficiently. However, the effect on reaction rates of concentration...

journal_title：Malaria journal

authors： Ambele MA,Egan TJ

更新日期：2012-10-08 00:00:00

abstract：BACKGROUND:Appropriate case management of suspected malaria in Cambodia is critical given anti-malarial drug resistance in the region. Improving diagnosis and the use of recommended malarial treatments is a challenge in Cambodia where self-treatment and usage of drug cocktails is widespread, a notable difference from m...

journal_title：Malaria journal

authors： O'Connell KA,Samandari G,Phok S,Phou M,Dysoley L,Yeung S,Allen H,Littrell M

更新日期：2012-10-05 00:00:00

abstract：BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...

journal_title：Malaria journal

authors： Okell LC,Paintain LS,Webster J,Hanson K,Lines J

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Polymorphisms within the PfATP6 gene have been indicated as potential molecular markers for artemisinin efficacy. Since 2004, the use of artemisinin combination therapy (ACT) was introduced as first-line treatment of the uncomplicated malaria cases in Suriname. The aim of this research was to determine chang...

journal_title：Malaria journal

authors： Adhin MR,Labadie-Bracho M,Vreden SG

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...

journal_title：Malaria journal

authors： Wong RP,Flematti GR,Davis TM

更新日期：2012-09-07 00:00:00

abstract：BACKGROUND:Mosquito transgenesis offers new promises for the genetic control of vector-borne infectious diseases such as malaria and dengue fever. Genetic control strategies require the release of large number of male mosquitoes into field populations, whether they are based on the use of sterile males (sterile insect ...

journal_title：Malaria journal

authors： Marois E,Scali C,Soichot J,Kappler C,Levashina EA,Catteruccia F

更新日期：2012-08-28 00:00:00

abstract：BACKGROUND:Drug and multidrug-resistant Plasmodium falciparum malaria has existed in Thailand for several decades. Furthermore, Thailand serves as a sentinel for drug-resistant malaria within the Greater Mekong sub-region. However, the drug resistance situation is highly dynamic, changing quickly over time. Here parasi...

journal_title：Malaria journal

authors： Parker D,Lerdprom R,Srisatjarak W,Yan G,Sattabongkot J,Wood J,Sirichaisinthop J,Cui L

更新日期：2012-08-21 00:00:00

abstract：BACKGROUND:Studies in South-East Asia have suggested that early diagnosis and treatment with artesunate (AS) and mefloquine (MQ) combination therapy may reduce the transmission of Plasmodium falciparum malaria and the progression of MQ resistance. METHODS:The effectiveness of a fixed-dose combination of AS and MQ (ASM...

journal_title：Malaria journal

authors： Santelli AC,Ribeiro I,Daher A,Boulos M,Marchesini PB,dos Santos RL,Lucena MB,Magalhães I,Leon AP,Junger W,Ladislau JL

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...

journal_title：Malaria journal

authors： Mens PF,Moers AP,de Bes LM,Flint J,Sak JR,Keereecharoen L,van Overmeir C,Verweij JJ,Hallett RL,Wihokhoen B,Proux S,Schallig HD,van Amerongen A

更新日期：2012-08-17 00:00:00

abstract：BACKGROUND:Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs s...

journal_title：Malaria journal

authors： Mugasa J,Qi W,Rusch S,Rottmann M,Beck HP

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:Despite some problems related to accuracy and applicability, malaria rapid diagnostic tests (RDTs), are currently considered the best option in areas with limited laboratory services for improving case management and reducing over-treatment. However, their performance must be established taking into the acco...

journal_title：Malaria journal

authors： Muhindo HM,Ilombe G,Meya R,Mitashi PM,Kutekemeni A,Gasigwa D,Lutumba P,Van Geertruyden JP

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). METHODS:This study was a series of qualit...

journal_title：Malaria journal

authors： Kaufman MR,Rweyemamu D,Koenker H,Macha J

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, ...

journal_title：Malaria journal

authors： Pribluda VS,Barojas A,Añez A,López CG,Figueroa R,Herrera R,Nakao G,Nogueira FH,Pianetti GA,Povoa MM,Viana GM,Gomes MS,Escobar JP,Sierra OL,Norena SP,Veloz R,Bravo MS,Aldás MR,Hindssemple A,Collins M,Ceron N,Kris

更新日期：2012-06-15 00:00:00

abstract：BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...

journal_title：Malaria journal

authors： Okello G,Ndegwa SN,Halliday KE,Hanson K,Brooker SJ,Jones C

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost, poor availability, and technical difficulty. With the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analys...

journal_title：Malaria journal

authors： Kafsack BF,Painter HJ,Llinás M

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...

journal_title：Malaria journal

authors： Kang S,Jung J,Lee S,Hwang H,Kim W

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

journal_title：Malaria journal

authors： Fu Y,Ding Y,Zhou T,Fu X,Xu W

更新日期：2012-04-01 00:00:00

abstract：:An improved methodology is presented here for transgenic Plasmodium berghei lines that express the negative selectable marker yFCU (a bifunctional protein that combines yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT)) and substitutes delivery of selection drug 5-fluorocytosine (5FC) by intraperit...

journal_title：Malaria journal

authors： Orr RY,Philip N,Waters AP

更新日期：2012-03-31 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been recommended for the treatment of falciparum malaria by the World Health Organization. Though India has already switched to ACT for treating falciparum malaria, there is need to have multiple options of alternative forms of ACT. A randomized trial was condu...

journal_title：Malaria journal

authors： Anvikar AR,Sharma B,Shahi BH,Tyagi PK,Bose TK,Sharma SK,Srivastava P,Srivastava B,Kiechel JR,Dash AP,Valecha N

更新日期：2012-03-30 00:00:00